Möchten Sie über diese Zeitschrift informiert bleiben? Klicken Sie bitte auf die Buttons, um unsere Alerts zu abonnieren.
Möchten Sie über diese Zeitschrift informiert bleiben? Klicken Sie bitte auf die Buttons, um unsere Alerts zu abonnieren.
Mushrooms versus fungi: natural compounds from Lentinula edodes inhibit aflatoxin biosynthesis by Aspergillus parasiticus
in World Mycotoxin JournalSearch for other papers by M. Reverberi in
Current site
Google Scholar
Search for other papers by S. Zjalic in
Current site
Google Scholar
Search for other papers by A. Ricelli in
Current site
Google Scholar
Search for other papers by C. Di Meo in
Current site
Google Scholar
Search for other papers by M. Scarpari in
Current site
Google Scholar
Search for other papers by C. Fanelli in
Current site
Google Scholar
Search for other papers by A. Fabbri in
Current site
Google Scholar
Although the strategies routinely adopted to limit production of carcinogenic aflatoxins by Aspergillus parasiticus and Aspergillus flavus in foods and feeds can be quite effective, they are often neither environmentally friendly, nor non-toxic for end users. Polysaccharides and glycoproteins, particularly β-glucans from the basidiomycete Lentinula edodes, already known for their health-promoting effects on animals and humans, have previously demonstrated the ability to inhibit aflatoxin biosynthesis by stimulating the antioxidant defences of the toxigenic fungus. Here the results of a study regarding the influence on polysaccharide production by L. edodes of oxidative stress induced using paraquat (PQ) treatment are reported. Paraquat 0.5 and 1 mM resulted in an enhancement of the expression of the β-glucan synthase gene Lefks1 and a consequent stimulating effect (about 30-35%) on β-glucans production. Moreover, oxidative-stress (PQ) induced polysaccharides have a higher aflatoxin inhibiting capacity in two different strains of A. parasiticus in comparison with non-induced polysaccharides. This more efficient inhibition might be explained by a higher content of β-glucans because 1H-NMR analysis revealed no obvious qualitative differences between PQ-induced and non-induced polysaccharides. The results obtained show promise for improving the quantity and efficiency of L. edodes extracts in order to achieve enhanced control over aflatoxin biosynthesis in foods and feeds using health-promoting and environmentally-friendly compounds.
Kauf
Sofortzugang erwerben (PDF-Download und unbegrenzter Online-Zugang):
Institutszugang
Melden Sie sich mit Open Athens, Shibboleth oder Ihren institutionellen Anmeldedaten an.
Persönliche Anmeldung
Melden Sie sich mit Ihrem brill.com-Konto an
-
Fanelli, C., Tasca, V., Ricelli, A., Reverberi, M., Zjalic, S., Finotti, E. and Fabbri, A.A., 2000. Inhibiting effect of medicinal mushroom Lentinus edodes (Berk.) Sing (Agaricomycetideae) on aflatoxin production by Aspergillus parasiticus Speare. International Journal of Medicinal Mushrooms 2: 229-236.
-
Golob, P., Farrell, G. and Orchard, J.E. (eds.), 2002. Crop postharvest: science and technology, vol. 1. Blackwell Science-Greenwich University, Oxford, UK, 582 pp.
-
Jackson, P.E. and Groopman, J.D., 1999. Aflatoxin and liver cancer. Best Practice and Research Clinical Gastroenterology 13: 545-544.
-
Jayashree, T. and Subramanyam, C., 2000. Oxidative stress as a prerequisite for aflatoxin production by Aspergillus parasiticus. Free Radical Biology and Medicine 29: 981-985.
'Oxidative stress as a prerequisite for aflatoxin production by Aspergillus parasiticus ' () 29 Free Radical Biology and Medicine : 981 -985 .
-
Kim, J.H., Yu, J., Mahoney, N., Chan, K.L., Molyneux, R.J., Varga, J., Bhatnagar, D., Cleveland, T.E., Nierman, W.C. and Campbell, B.C., 2008. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. International Journal of Food Microbiology 122: 49-60.
'Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis ' () 122 International Journal of Food Microbiology : 49 -60 .
-
Koehler, L.H., 1952. Differentiation of carbohydrates by anthrone reaction rate and color intensity. Analytical Chemistry 24: 576-579.
'Differentiation of carbohydrates by anthrone reaction rate and color intensity ' () 24 Analytical Chemistry : 576 -579 .
-
Krcmar, P., Novotny, C., Marais, M.F. and Joseleau, J.P., 1999. Structure of extracellular polysaccharide produced by lignin degrading fungus Phlebia radiata in liquid culture. International Journal of Biological Macromolecules 64: 61-64.
'Structure of extracellular polysaccharide produced by lignin degrading fungus Phlebia radiata in liquid culture ' () 64 International Journal of Biological Macromolecules : 61 -64 .
-
Moradali, M.F., Mostafavi, H., Ghods, S. and Hedjaroude, G.A., 2007. Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). International Immunopharmacology 7: 701-724.
'Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi) ' () 7 International Immunopharmacology : 701 -724 .
-
Osman, A.M. and Van Noort, P.C.M., 2004. Activation of paraquat in the earthworm Allolobophora chlorotica is mediated by NAD(P) H-cytochrome c reductase activities. Pesticide Biochemistry and Physiolology 79: 101-110.
'Activation of paraquat in the earthworm Allolobophora chlorotica is mediated by NAD(P) H-cytochrome c reductase activities ' () 79 Pesticide Biochemistry and Physiolology : 101 -110 .
-
Reverberi, M., Di Mario, F. and Tomati, U., 2004. β-glucan synthase induction in mushrooms grown on olive oil mill wastewaters. Applied Microbiology and Biotechnology 66: 217-225.
'β-glucan synthase induction in mushrooms grown on olive oil mill wastewaters ' () 66 Applied Microbiology and Biotechnology : 217 -225 .
-
Reverberi, M., Fabbri, A.A., Zjalic, S., Ricelli, A., Punelli, F. and Fanelli, C., 2005. Antioxidant enzymes stimulation in Aspergillus parasiticus by Lentinula edodes inhibits aflatoxin production. Applied Microbiology and Biotechnology 69: 207-215.
'Antioxidant enzymes stimulation in Aspergillus parasiticus by Lentinula edodes inhibits aflatoxin production ' () 69 Applied Microbiology and Biotechnology : 207 -215 .
-
Reverberi, M., Zjalic, S., Ricelli, A., Fabbri, A.A. and Fanelli, C., 2006. Oxidant/antioxidant balance in Aspergillus parasiticus affects aflatoxin biosynthesis. Mycotoxin Research 22: 39-47.
'Oxidant/antioxidant balance in Aspergillus parasiticus affects aflatoxin biosynthesis ' () 22 Mycotoxin Research : 39 -47 .
-
Reverberi, M., Zjalic, S., Ricelli, A., Punelli, F., Camera, E., Fabbri, C., Picardo, M., Fanelli, C. and Fabbri, A.A., 2008. Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene. Eukaryotic Cell 7: 988-1000.
'Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene ' () 7 Eukaryotic Cell : 988 -1000 .
-
Slamenova, D., Labaj, J., Krizkova, L., Kogan, G., Sandula, J., Bresgen, N. and Eckl, P., 2003. Protective effect of fungal (1-3)-β-D-glucan derivates against oxidative DNA lesions in V79 hamster lung cells. Cancer Letters 198: 153-160.
'Protective effect of fungal (1-3)-β-D-glucan derivates against oxidative DNA lesions in V79 hamster lung cells ' () 198 Cancer Letters : 153 -160 .
-
Tolaini, V., Zjalic, S., Reverberi, M., Fanelli, C., Fabbri, A.A. and Ricelli, A., 2010. Lentinula edodes enhances the biocontrol activity of Cryptococcus laurentii against Penicillium expansum contamination and patulin production in apple fruits. International Journal of Food Microbiology 138: 243-249.
'Lentinula edodes enhances the biocontrol activity of Cryptococcus laurentii against Penicillium expansum contamination and patulin production in apple fruits ' () 138 International Journal of Food Microbiology : 243 -249 .
-
Vis, R.B. and Lorenz, K., 1997. β glucans: importance in brewing and methods of analysis. Lebensmittel-Wissenschaft und -Technologie 30: 331-336.
'β glucans: importance in brewing and methods of analysis ' () 30 Lebensmittel-Wissenschaft und -Technologie : 331 -336 .
-
Wasser, S.P. and Weis, A., 1999. Medicinal properties of substances occurring in higher basidiomycete mushroom: current perspectives. International Journal of Medicinal Mushrooms 1: 31-62.
'Medicinal properties of substances occurring in higher basidiomycete mushroom: current perspectives ' () 1 International Journal of Medicinal Mushrooms : 31 -62 .
-
Zjalic, S., Fabbri, A.A., Reverberi, M., Ricelli, A., Punelli, F. and Fanelli, C., 2007. Use of Trametes versicolor in control of aflatoxins produced by Aspergillus parasiticus. International Journal of Medicinal Mushrooms 9: 236-237.
'Use of Trametes versicolor in control of aflatoxins produced by Aspergillus parasiticus ' () 9 International Journal of Medicinal Mushrooms : 236 -237 .
-
Zjalic, S., Reverberi, M., Ricelli, A., Granito, V.M., Fanelli, C. and Fabbri, A.A., 2006. Trametes versicolor: a possible tool for aflatoxin control. International Journal of Food Microbiology 107: 243-249.
'Trametes versicolor: a possible tool for aflatoxin control ' () 107 International Journal of Food Microbiology : 243 -249 .
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 233 | 73 | 5 |
| Gesamttextansichten | 19 | 0 | 0 |
| PDF-Downloads | 12 | 0 | 0 |
Mushrooms versus fungi: natural compounds from Lentinula edodes inhibit aflatoxin biosynthesis by Aspergillus parasiticus
in World Mycotoxin JournalSearch for other papers by M. Reverberi in
Current site
Google Scholar
PubMed
Search for other papers by S. Zjalic in
Current site
Google Scholar
PubMed
Search for other papers by A. Ricelli in
Current site
Google Scholar
PubMed
Search for other papers by C. Di Meo in
Current site
Google Scholar
PubMed
Search for other papers by M. Scarpari in
Current site
Google Scholar
PubMed
Search for other papers by C. Fanelli in
Current site
Google Scholar
PubMed
Search for other papers by A. Fabbri in
Current site
Google Scholar
PubMed
Although the strategies routinely adopted to limit production of carcinogenic aflatoxins by Aspergillus parasiticus and Aspergillus flavus in foods and feeds can be quite effective, they are often neither environmentally friendly, nor non-toxic for end users. Polysaccharides and glycoproteins, particularly β-glucans from the basidiomycete Lentinula edodes, already known for their health-promoting effects on animals and humans, have previously demonstrated the ability to inhibit aflatoxin biosynthesis by stimulating the antioxidant defences of the toxigenic fungus. Here the results of a study regarding the influence on polysaccharide production by L. edodes of oxidative stress induced using paraquat (PQ) treatment are reported. Paraquat 0.5 and 1 mM resulted in an enhancement of the expression of the β-glucan synthase gene Lefks1 and a consequent stimulating effect (about 30-35%) on β-glucans production. Moreover, oxidative-stress (PQ) induced polysaccharides have a higher aflatoxin inhibiting capacity in two different strains of A. parasiticus in comparison with non-induced polysaccharides. This more efficient inhibition might be explained by a higher content of β-glucans because 1H-NMR analysis revealed no obvious qualitative differences between PQ-induced and non-induced polysaccharides. The results obtained show promise for improving the quantity and efficiency of L. edodes extracts in order to achieve enhanced control over aflatoxin biosynthesis in foods and feeds using health-promoting and environmentally-friendly compounds.
| Insgesamt | Letzte 365 Tage | In den letzten 30 Tagen | |
|---|---|---|---|
| Aufrufe von Kurzbeschreibungen | 233 | 73 | 5 |
| Gesamttextansichten | 19 | 0 | 0 |
| PDF-Downloads | 12 | 0 | 0 |
