Save

Beneficial effects of a probiotic blend on gastrointestinal side effects induced by leflunomide and amlodipine in a rat model

于Beneficial Microbes
著者:
S.-C. Song Department of Systems Biology, Yonsei University, 323, SB140, Yonsei-ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.

Search for other papers by S.-C. Song in
Current site
Google Scholar
PubMed
Close
,
Y.-M. An Department of Systems Biology, Yonsei University, 323, SB140, Yonsei-ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.

Search for other papers by Y.-M. An in
Current site
Google Scholar
PubMed
Close
,
J.-H. Shin R&D Center, Cell Biotech Co., Ltd., 50, Aegibong-ro 409 beon-gil, Wolgot-myeon, Gimpo-si, Gyeonggi-do 10003, Republic of Korea.

Search for other papers by J.-H. Shin in
Current site
Google Scholar
PubMed
Close
,
M.-J. Chung R&D Center, Cell Biotech Co., Ltd., 50, Aegibong-ro 409 beon-gil, Wolgot-myeon, Gimpo-si, Gyeonggi-do 10003, Republic of Korea.

Search for other papers by M.-J. Chung in
Current site
Google Scholar
PubMed
Close
,
J.-G. Seo R&D Center, Cell Biotech Co., Ltd., 50, Aegibong-ro 409 beon-gil, Wolgot-myeon, Gimpo-si, Gyeonggi-do 10003, Republic of Korea.

Search for other papers by J.-G. Seo in
Current site
Google Scholar
PubMed
Close
, and
E. Kim Department of Systems Biology, Yonsei University, 323, SB140, Yonsei-ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.

Search for other papers by E. Kim in
Current site
Google Scholar
PubMed
Close
Download Citation 获得许可

Access options

Get access to the full article by using one of the access options below.

Institutional Login

Log in with Open Athens, Shibboleth, or your institutional credentials

Login with Institutional Access

Purchase

Buy instant access (PDF download and unlimited online access):

€36.93

Patients with metabolic disorders frequently suffer from side effects induced by long-term oral medications. The present study using a rat model system indicated that leflunomide (LF) and amlodipine (AMD), the active ingredients contained in the medications for rheumatoid arthritis and hypertension, respectively, appeared to induce various bowel problems including constipation and inflammation. In the small and large intestine, LF increased the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 compared to the null control and AMD increased the expression of both TNF-α and IL-1β, although its effect on IL-6 was only increased in the large intestine. It is noteworthy that the probiotic blend tested was found to alleviate intestinal complications caused by LF and AMD. Analysis of the gut microbiota revealed that AMD induced compositional changes in the gut microbiota. Namely, members of the phylum Bacteroidetes, which constituted only about 0.3% of the microbiota in the null control, made up more than 10% of the total composition in the AMD-administered rats. Interestingly, the probiotic blend was also found to normaliSe the gut microbiota.

内容统计数据

全部期间 过去一年 过去30天
摘要浏览次数 680 239 18
全文浏览次数 17 4 1
PDF下载次数 25 9 4